02/19/2025
research article
Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine
Binding sites of biologically active FimH monoclonal antibodies were determined by X-ray crystallography or by cryo-electron microscopy, providing insights into mechanisms by which antibodies block binding of the bacteria to urinary tract receptors.
Image credit: ppat.1012325
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