03/31/2025
Research article
As SARS-CoV-2 continues to spread and adapt in humans, viral variants with enhanced spread and immune evasion have emerged throughout the COVID-19 pandemic. While most of the mutations occur in the Spike protein and have been extensively studied, non-Spike mutations have been accumulating and are not as well understood.
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Current Issue March 2025
03/31/2025
REVIEW
The successful transmission of malaria by Anopheles mosquitoes relies on complex successive interactions between the parasite and various mosquito organs, host factors, and restriction factors. This review summarizes our current understanding of the mechanisms regulating Plasmodium infection of the mosquito vector at successive plasmodial developmental stages and highlights potential transmission-blocking targets and strategies.
Image credit: ppat.1012965
03/31/2025
research article
Following pathogen infection, CD8 T cells eliminate infected cells and form diverse pools of memory T cells that are critical to prevent reinfection. Both the timing and intensity of inflammatory signals present during T cell activation play a major role in the subsequent phenotype of responding CD8 T cells.
Image credit: ppat.1012993
04/01/2025
research article
APOBEC3s are antiviral restriction factors that work by mutating viral DNA, thereby inhibiting virus replication. They are particularly potent against retroviruses. Unlike human APOBEC3 proteins, mouse APOBEC3 does not mutate retroviral DNA, but instead directly interferes with viral DNA synthesis, although the mouse protein retains its ability to mutate DNA.
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04/01/2025
research article
This study shows that T4519, a eukaryote-like serine threonine kinase promotes survival and growth of S. Typhi within macrophages
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04/02/2025
research article
Papain-like cysteine proteases (PLCPs) play critical roles in regulating plant immunity. Here, the authors identify a protein named NbPIRIN that inhibits Chinese wheat mosaic virus (CWMV) infection. The results reveal a previously unreported offensive and defensive strategy between plants and viruses.
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04/02/2025
Research article
The T3SS and ExoS each have impacts on bactericidal and inflammatory cell death responses in neutrophils.
Image credit: ppat.1013021
04/01/2025
Research article
This study provides new insight into the function and mechanism of a new class of latency reversing agent.
Image credit: ppat.1013018
03/18/2025
research article
The authors report a novel Betacoronavirus 1 isolated from goats suffering diarrhea in China, putatively named caprine coronavirus (cpCoV).
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03/11/2025
research article
This study demonstrates that IBDV infection promotes IL-1β production and activates the NF-κB signaling pathway.
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Brittany Seibert, C. Joaquín Cáceres, and colleagues
Qi-Yue Yang, Yong-Le Yang, and colleagues
Frideborg Bradley and colleagues
Jodie A. Schiffer & Stephanie V. Stumbur and colleagues
B. Karina Montero and colleagues
We are pleased to announce that Sumita Bhaduri-McIntosh joined us as second Editor-in-Chief at the beginning of 2025. With this addition, we are thrilled to once again have a dynamic dual leadership team guiding the journal.
We're excited about our revised and synchronized Editorial Board webpage—now enhanced with a brand-new search functionality!
Easily find and explore board members with our improved layout and seamless navigation.
We've been thrilled to welcome:
Helena Boshoff, Thomas Guillard, Thomas Hoenen, Francis Jiggins, Robert Kalejta, Tracey Lamb, Edward Mitre, and Alice Prince!
PLOS will always anchor our decisions in our values and our principles. And we will continue to speak up vocally for open, independent science.
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