PLOS statement on recent US Executive Orders

In this review, the authors propose focusing on the “pre-sepsis” phase, where early immune dysregulation occurs before significant organ damage. Developing tools to detect this initial host response to infection could enable earlier intervention and prevent progression to sepsis. Such an approach may improve clinical outcomes and support more personalized treatments targeting specific immune pathways tailored to patient profiles. 

Here, the authors utilized a nonhuman primate model to compare the effects of infection with the SARS-CoV-2 delta variant in lean and obese/insulin-resistant adult male rhesus macaques over a 6-month period.

Here, the authors identified a conserved chaperonin (CPN) complex whose CPN60 subunit is essential, with its loss causing immediate parasite death from organellar damage in the first replication cycle. CPN60 binds and stabilizes the Clp complex, showing how balanced refolding and proteolysis safeguard the apicoplast proteome.